This article explores the transformative role of AI and real-world data in healthcare, complementing traditional randomized clinical trials (RCTs). While RCTs remain the gold standard, they often don’t capture the diversity of real-world clinical practice. AI, leveraging vast datasets from electronic health records, can compare treatment effectiveness across diverse patient populations. The article emphasizes the importance of collaboration between physicians and AI developers to create clinically relevant and secure AI tools. It also highlights AI’s potential to democratize access to high-quality care, ensuring broader patient benefits.